Abnormal growth hormone release in response to human pancreatic growth hormone releasing factor in acromegaly.
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چکیده
منابع مشابه
Abnormalities of growth hormone release in response to human pancreatic growth hormone releasing factor (GRF (1-44) ) in acromegaly and hypopituitarism.
Human pancreatic growth hormone releasing factor (GRF (1-44)) is the parent molecule of several peptides recently extracted from pancreatic tumours associated with acromegaly. A study was conducted to examine its effects on the release of growth hormone in normal volunteers and in patients with hypopituitarism and acromegaly. GRF (1-44) dose dependently stimulated the release of growth hormone ...
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Responses of growth hormone (GH) release to synthetic human growth hormone-releasing factor (hGRF)-44-NH2 analogs were determined, and the GH-releasing potency based on dose per kg of body weight (bw) was compared with that of hGRF-44-NH2 in female dairy calves. Four- and 12-month-old calves were injected intravenously with 0.25 microgram of hGRF-44-NH2 or its analogs per kg of bw. Blood sample...
متن کاملGrowth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice
OBJECTIVE To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormone-releasing hormone receptors. MATERIALS AND METHODS The responses of serum growth hormone to acutely injected growth hormone-releasing P-2 in lit/lit mice, which represent a model of ...
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An abnormal hyperresponse of GH to intravenous injection of TRH in a 66-year-old female pellagra patient with typical 3'D's was reported. Diagnosis of pellagra was mainly based on her clinical course and manifestations, although serum levels of nicotinic acid and serotonin were within the normal range. Serum vitamin A and B2 levels were low. However, these findings did not exclude the diagnosis...
متن کاملEffect of growth hormone-releasing factor (1-29)NH2 and thyrotropin-releasing factor on growth hormone release in lactating sows.
Résumé. Vingt-six truies en lactation ont reçu les traitements suivants : 1) solution saline physiologique ; 2) somatocrinine ou hGRF(1-29)NH 2(20 ¡lg.kg1) ; 3) thyréolibérine (TRF) (1 ¡lg.kg) ; 4) combinaison de GRF et de TRF (20 et 1 ¡lg.kgrespectivement). La solution saline ou les peptides ont été injectés par voie sous-cutanée, deux fois par jour, du 5e au 25e jour post-partum. Les niveaux ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1983
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.286.6383.2063